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Phosphodiesterase 5 inhibitors (PDE5Is) like Viagra (Sildenafil), Levitra (Vardenafil), and Cialis (Tadalafil) have stormed the sexual health field, safely bringing patients harder, longer-lasting erections for over 30 years. Each of these medications packs a special punch that makes them unique and potentially more effective for certain individuals than others

But for some, one PDE5I may not be enough to achieve the rock-hard erections that they’re looking for or effectively keep you covered during the window of opportunity for sexual encounters. Fortunately, research has demonstrated that combining multiple PDE5Is may lead to harder, longer-lasting erections without any additional side effects.

This is where BlueChew MAX Combos come into play. 

BlueChew MAX Combos are crafted for patients with diverse needs. If you’re looking to be ready at a moment’s notice and enjoy continuous benefits, you might have just found your perfect match.

BlueChew offers two combination compounded tablets, each containing two specifically selected PDE5 inhibitors, to help you achieve the stand-up results you want.

Below, we’ll explore what PDE5 inhibitors are, how they work, and why combining them can give you the significant boost in the bedroom you’ve been after. Plus, we’ll discuss how to get BlueChew MAX Combos through our easy-to-use telehealth service.

What Are PDE5 Inhibitors?

PDE5 inhibitors are a class of medications initially designed to treat high blood pressure and chest pain (angina). Patients in clinical trials for these drugs started noticing some interesting unintended effects – harder and longer-lasting erections.

Shortly after that, the first PDE5 inhibitor, Viagra (Sildenafil), was FDA-approved for enhancing erections in 1998. In the coming years, two other PDE5 inhibitors, Levitra (Vardenafil) and Cialis (Tadalafil), gained FDA approval, each with its own unique benefits, such as a faster onset of action and longer duration of action compared to the original prototype.

How Do PDE5 Inhibitors Work?

Enhancing erections is all about improving blood flow. Erections occur when the blood vessels in the penis dilate (widen) in response to sexual stimulation. This leads to more blood flow into the penis, making it more rigid as it fills with blood.

PDE5 inhibitors help support better erections by boosting natural blood flow into the penis, making your erections harder than ever before. 

But how do they do this?

These drugs work by blocking the action of an important enzyme known as phosphodiesterase 5 (PDE5). When PDE5 is blocked, it causes the build-up of cyclic guanosine monophosphate (cGMP), a chemical in the body responsible for releasing nitric oxide (NO). When NO is released, it dilates blood vessels.

By preventing PDE5 from breaking down cGMP, these medications seriously increase NO levels. More NO relaxes vascular smooth muscle cells, dilating blood vessels, allowing more blood to flow to the penis. 

This increased blood flow to the penis causes a rock-hard, long-lasting erection when you become sexually aroused.

Common PDE5 inhibitors

Each PDE5 inhibitor has its own unique set of perks, and often combining them can significantly improve your sexual performance. Below, we’ll dive into the three big players in the erection-enhancement world and check out the key differences. 

Whether you’re looking for quick action, long-lasting coverage, or the best of both worlds, we’ve got the scoop on how these options can work alone (or together) to give you the best results in the bedroom.

Sildenafil (Viagra)

Sildenafil is a prescription drug best known for its quick effects (it starts working within 30 to 60 minutes, although it may get some patients going in as little as 12 minutes) and shorter duration times (4 to 6 hours). Most patients will take Sildenafil as needed (aka when the night seems it may be headed in an exciting direction).

Combined, these effects typically make Sildenafil the best choice for a date night or planned sexual activity.

Pro tip: if you take this medication with a meal, particularly one high in fats (think fried, greasy foods), you might be waiting a bit longer for the magic to happen. High-fat meals can slow absorption and dull the effects, so it might be best to save that heavy meal for after sexual activity.

Vardenafil (Levitra)

Vardenafil is very similar to Sildenafil when it comes to its onset of action (typically 30 minutes, although there has been research of effects starting in only 10 minutes), shorter duration time (4 to 6 hours), and slight interaction with food (it may not work as well if you just had a big greasy meal). Vardenafil is also usually taken as needed, meaning it’s best to take it before things get steamy. 

Here’s where Vardenafil steps up its game: strength and selectivity. 

Vardenafil is up to 10 times more potent than Sildenafil, meaning most patients need a lower dose to experience the same erection-enhancing effects, which may mean a lower risk of side effects. Also, because Vardenafil is more selective (blocks the PDE5 inhibitor more precisely in the penis), it may reduce the risk of some very rare side effects associated with Sildenafil, such as changes in vision.

Vardenafil is an excellent choice for patients looking for a big boost in the bedroom on a special occasion who may not have achieved the results they were looking for with Sildenafil.

Tadalafil (Cialis)

Tadalafil stands out among other PDE5Is for its extended duration of action – keeping your rock-hard erections going for up to 24 to 36 hours. It kicks in quickly, too (usually within 30 minutes). And the best part? You don’t have to worry about how heavy your meal is as Tadalafil doesn’t interact with food.

You can take a Tadalafil tablet as needed for those special nights or take it daily for a bit of all-day, everyday readiness. Imagine turning a single date night into a romantic weekend away or just being prepared for those spontaneous sexual moments that come out of nowhere. 

With daily use of Tadalafil, you’ll always be performing at your best, so when the mood strikes, you’re more than ready to make it happen. 

Why combine PDE5 inhibitors?

Although PDE5 inhibitors have proven to be effective and safe for most individuals looking for a boost in the bedroom, for some men, taking only one PDE5 inhibitor may not hit all of the marks.

We’ll examine the top benefits of combining PDE5Is to help you perform at your best in the bedroom.

Better results

Taking a combination of PDE5Is may lead to better results in the bedroom. 

A 2014 study found that men taking 5 mg of Tadalafil daily with 50 mg of Sildenafil, compared to men taking only 5 mg of Tadalafil when needed, had more significant improvements in erectile function (including enhancements in erection quality, confidence, penetration, and sexual satisfaction). 

Another 2024 study found that men who had not previously responded to PDE5Is improved their erectile function and rigidity when they received a combination of 5 mg of Tadalafil (daily) and 100 mg of Sildenafil (as needed).

If one PDE5I isn’t producing the desired results, a combination could be the key to turning up the heat between the sheets.

Minimized side effects

Did you know that combining PDE5Is can minimize the risk of unwanted side effects?

By combining two PDE5 inhibitors, men may require a lower dosage of each medication. Lower dosages reduce the risk of side effects compared to taking the maximum medication dosage.

Scientific evidence supports these findings. A 2014 study revealed that men who combined Tadalafil with Sildenafil experienced no additional side effects.  

This means that with BlueChew MAX Combos, you can experience the rock-hard erections you want without the increased risk of uncomfortable side effects.

Tailored treatment

A combination approach can help tailor your treatment to meet your specific needs. Taking a combination of PDE5Is with different onset times and durations of action can fit your individual lifestyle and sexual activity patterns.

By combining a potent, short-acting PDE5I with the long-lasting effects of Tadalafil, you can expect quick results and stronger erections for up to 36 hours. This allows you to take the pressure off of the time frame and ease any anxiety while adding spontaneity to your sex life.

Instead of settling for just some of the perks of a single PDE5I, you can have them all with BlueChew MAX Combos.

BlueChew MAX Combos 

BlueChew offers two MAX Combos, including Sildenafil + Tadalafil or Vardenafil + Tadalafil, both conveniently available in one chewable tablet. We’ll get into the nitty-gritty behind each combination tablet and help you decide which may be right for you.

Sildenafil + Tadalafil Combo

This BlueChew MAX Combo contains 45 mg of Sildenafil and 9 mg of Tadalafil in one convenient chewable tablet. This compounded medication will have you covered for quick erection enhancement and long-lasting coverage to allow for a reinvigorated, spontaneous sex life.

Combining Sildenafil and Tadalafil may provide a plethora of benefits, including:

• Rapid onset of action (approximately 30 minutes, but can take effect in as little as 12 minutes).
• Long-lasting coverage (24 to 36 hours of enhanced erections).
• Enhanced effects – combining two PDE5Is may be more effective than using a single agent. 
• Tadalafil does not interact with food, so eating a meal with this chewable tablet will not significantly affect the effects.
• Potential for minimized side effects due to utilization of two PDE5Is at safe doses.

Vardenafil + Tadalafil Combo

This unique BlueChew MAX Combo contains 8 mg of Vardenafil and 9 mg of Tadalafil in a single chewable tablet. BlueChew’s blend of a short-acting and highly selective PDE5I with a long-lasting erection-enhancing medication will have you ready for a romp between the sheets quicker than ever before and keep you covered for spontaneous sexual activity.

Combining Vardenafil and Tadalafil provides a range of benefits, including:

• Rapid onset of action (approximately 30 minutes, but can take effect in as few as 10 minutes).
• Long-lasting erection enhancement (24 to 36 hours).
• Increased effectiveness – combining multiple PDE5Is may be more effective than using a single agent.   
• Tadalafil does not interact with food, so eating with this chewable tablet will not significantly interfere with the intended effects.
• Potentially reduced side effects of a combination compared to a high dose of a single PDE5I.

Potential Health Benefits of PDE5 Inhibitors

Besides the range of sexual health benefits that PDE5Is offer, research has demonstrated that these medications may also boost your health. 

Although not FDA-approved for these uses, taking PDE5Is may result in the following health benefits:

• Reduced cardiovascular risk and the risk of death from major cardiovascular events associated with cardiovascular disease.
• Enhanced cognition, memory, mood, exercise capacity, and skeletal muscle oxygenation 
• Reduced inflammation, oxidative stress, waist circumference, abdominal fat, and blood pressure.
• Increased muscle protein synthesis, lean muscle mass, and testosterone levels.
• Improved fat metabolism, blood vessel health, and blood sugar control.
• Improved prostate/urinary health and prevents kidney damage.
• Reduced risk of complications secondary to a stroke.
• Support bone maintenance, repair, and development.
• Enhanced immune function.
• Protects nerves, prevents their degeneration, and promotes their growth
• Reduced chronic pain and neuropathic pain.

If you’re curious to learn the unique health benefits of each PDE5I, check out our blog posts on Sildenafil, Vardenafil, and Tadalafil. 

Potential side effects

Each BlueChew MAX Combo tablet contains prescription medications and, like all prescription drugs, comes with the risk of side effects. Common side effects to look out for include:

• Headache
• Nasal congestion
• Flushing
• Back and muscle pain
• Upset stomach

More rare but serious adverse effects can also occur. These include:

• Sudden changes in vision or loss of hearing 
• Prolonged or painful erection lasting longer than 4 hours
• Chest pain or irregular heartbeat

If you experience any of these side effects, consult a BlueChew healthcare professional to ensure your safety. 

Additionally, certain health conditions may make taking PDE5Is dangerous. These health conditions include heart disease, unstable angina, recent heart attack, heart valve problems, severe heart rhythm problems, or resting hypotension. If you have any health concerns, it is essential to consult a healthcare professional before starting any PDE5I. 

Have additional questions? Check out our FAQ page, where we answer common questions about PDE5Is.

Final Thoughts

If you’re aiming for more satisfying sex on your terms, BlueChew MAX Combos could be just what you’re looking for. These chewables enhance blood flow to provide harder, longer-lasting erections.

By combining a fast-acting PDE5I with long-lasting Tadalafil, you can expect rapid onset and rock-hard erections that last anywhere from 24 to 26 hours. These MAX Combos will ensure you’re always ready for any intimate moment that comes your way.

With two unique options available at BlueChew, you can customize your treatment to match your specific needs.

Plus, the potential health benefits of these medications might give you a boost beyond the bedroom.

BlueChew MAX Combos may help you reach new levels of performance and confidence wherever life takes you.

How To Get BlueChew MAX Combos Through BlueChew

The MAX Combos offered through BlueChew can provide you with enhanced sexual experiences both around the clock and on-demand, helping you feel like a rockstar in the bedroom. 

BlueChew makes it easy. Select a plan, complete an online intake, and you’re done. A medical provider will review your information and, if appropriate, prescribe your plan, which will be shipped directly to your door.

No doctor appointments or patient support charges make it a stress-free experience.

With plans starting as low as $25 per month, BlueChew can fit into anyone’s budget. Plus, there’s no commitment—you can easily cancel or switch plans anytime.
Click here to explore all plan options for treatments at BlueChew.

FAQS

Does a high-fat meal interact with BlueChew MAX Combos?

High-fat meals (such as burgers, fries, ice cream, etc.) can interact with the effects of Sildenafil and Vardenafil. Eating these foods may affect how the medication works, making it take longer to take effect and weakening its impact. For optimal results, these ED medications are best taken on an empty stomach. Tadalafil, on the other hand, does not interact with foods, so it is safe to take with or without a meal. 

Are there side effects to BlueChew MAX Combos?

Like all prescription drugs, BlueChew MAX Combos come with the potential for side effects. Common side effects of oral medications include headache, nasal congestion, back or muscle pain, and upset stomach.

More rare and severe adverse effects can occur and include sudden loss of hearing, prolonged erection, visual abnormalities, or a life-threatening arrhythmia. If any of these side effects occur, seek immediate medical attention.

There is the potential for drug interactions with BlueChew MAX Combos. If you are taking alpha-blockers or other medications that treat high blood pressure, be sure to notify your doctor, as these medications can result in a dangerous drop in blood pressure when combined with PDE5Is, known as hypotension.

Why combine two erectile dysfunction (ED) drugs?

Treating ED can be complicated for some men if one medication doesn’t provide the results you are looking for. Combining ED drugs may be more effective and result in harder, more satisfying erections. With BlueChew, it’s simple. Fill out your medical intake and allow one of our online providers to determine if you are an eligible candidate for a combination of these medications.

Do compounded medications work the same as brand-name ED treatments?

The compounded medications from BlueChew contain the same active ingredients as Cialis, Viagra, and Levitra. They contain the same active ingredients as their brand-name counterparts, so you can expect the same impressive results when you take your daily dose. 

What other conditions do PDE5Is treat?

PDE5Is have been FDA-approved for treating other health issues, such as benign prostatic hyperplasia (enlarged prostate) and pulmonary hypertension. Although not FDA-approved for these conditions, it has also shown promise in helping with the treatment of premature ejaculation, Raynaud’s phenomenon, and chronic pain. These health claims are based on promising results from evidence-based research studies.

This article is for informational purposes only and does not constitute medical advice. The content provided here is not a substitute for, and should never be relied upon as, professional medical advice. Always consult your doctor to discuss the risks, benefits, and appropriateness of any treatment. BlueChew offers compounded medications prescribed solely for the treatment of erectile dysfunction and sexual performance enhancement. Compounded medications are not FDA-approved.

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